MITOCHONDRIAL DIVISION INHIBITOR (MDIVI-1) INDUCES EXTRACELLULAR MATRIX (ECM)-DETACHMENT OF VIABLE BREAST CANCER CELLS BY A DRP1-INDEPENDENT MECHANISM

Abstract Increasing evidence supports the hypothesis that cancer progression is under mitochondrial control.Mitochondrial fission plays a pivotal role in the maintenance of cancer cell homeostasis.The inhibition of DRP1, the main regulator of mitochondrial fission, with the mitochondrial COCONUT MILK ORG division inhibitor (mdivi-1) had been associ

Introduction: Coronary microvascular disease is one of the responsible factors for cardiac perfusion impairment.Due to diagnostic and treatment challenges, this pathology (characterized by alterations to microvasculature local hemodynamics) represents a significant yet unsolved clinical problem.Methods: Due to the poor understanding of the onset an

The study of twins provides a unique opportunity to evaluate the genetic and nongenetic contributions to a DHA variance of multitude of traits.Twin research has revealed the impact of a strong genetic component to the variance of many dental traits.The present study was conducted to assess the dental caries and oral hygiene status in monozygotic (M

This paper deals with a study of the failure mode of thin PVD coatings in alternated contact with molten aluminum alloy.CrN and ZrN monolayer coatings deposited through cathodic arc evaporation were used.The coatings morphology was assessed by SEM and their mechanical properties evaluated by nanohardness test performed at ORIG HOT SAUCE room temper